Welcome to Journal Of Pakistan Medical Association
   Issue Vol:65, No:9 September, 2015
Editorial >>

Understanding the pathogenesis of focal segmental glomerulosclerosis: morphology vs. molecules

Muhammed Mubarak,

The term focal segmental glomerulosclerosis (FSGS) describes the morphological appearance of glomerular lesions under the light microscope (LM) resulting from a large number of both primary and secondary glomerular diseases.1,2 But a widespread use of the term has led to a ....

Original Articles >>

Effectiveness of simple control measures on methicillin-resistant Staphylococcus aureus infection status and characteristics with susceptibility patterns in a teaching hospital in Peshawar

Muhammad Salman Rafiq, Muhammad Imran Rafiq, Taimur Khan, Maria Rafiq, Mah Muneer Khan,

Objective: To determine the effectiveness of simple control measures on the infection status and characteristics of methicillin-resistant Staphylococcus aureus including susceptibility patterns among health professionals and patients in a teaching hospital.
Methods: The cross....

Echocardiographic findings before and after surgical repair of Tetralogy of Fallot

Noor Mohammad Noori, Maziar Mahjoubifard, Seyed Mostafa Alavi, Alireza Teimouri,

Objective: To compare echocardiographic findings before and after surgical repair of Tetralogy of Fallot.
Methods: The interventional study was conducted in Ali-ebne-Abitaleb Hospital, Zahedan, Iran, from September 2008 to March 2010, and comprised patients undergoing surgica....

Pattern of dyslipidaemia and impact of increasing age and duration of type 2 diabetes mellitus on dyslipidaemia, insulin levels and insulin resistance

Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Muhammad Aslam, Arif Siddiqui, Ghulam Mustafa Lodhi,

Objectives: To study the pattern of dyslipidaemia in Type 2 Diabetes Mellitus patients and to determine the correlation of increasing age and duration of the disease with dyslipidaemia, insulin level and insulin resistance in diabetic patients.
Methods: The cross-sectional ca....

The specificity and sensitivity of ultrasonography in the diagnosis of acute right lower quadrant pain in women of child bearing age

Shumaila Arooj, Arfanul Haq, Zafar Amin,

Objective: To assess the sensitivity and specificity of ultrasonography in differentiating causes of acute right lower quadrant pain in women of child-bearing age by taking surgical outcome as the gold standard.
Methods: The descriptive analytical study was conducted at PNS S....

Schizophrenia diagnosis and treatment by general practitioners: A cross-sectional study in district Peshawar, Pakistan

Muhammad Irfan, Jose Miguel Caldas de Almeida, Uma Maheswari Irfan, Usman Ahmad Raza, Saeed Farooq,

Objective: To assess the knowledge and practices of general practitioners about diagnosis and treatment of schizophrenia and determine their association with clinical exposure to such cases in practice.
Methods: The cross-sectional study was conducted in Peshawar from August ....

Pervasiveness of intestinal protozoan and worm incursion in IDP's (North Waziristan agency, KPK-Pakistan) children of 6-16 years

Wasim Ahmed, Mushtaq Ahmad, Rafatullah, Faridullah Shah, Sajadullah,

Objective: To evaluate the prevalence of intestinal protozoan and worm infestation in children of families having migrated due to military operation.
Methods: The cross-sectional, descriptive study was conducted in Cantonment Military Hospital, Bannu, from August 4 to October....

High prevalence of vitamin D deficiency and insufficiency in a low income peri-urban community in Karachi

Naseema Mehboobali, Saleem Perwaiz Iqbal, Mohammad Perwaiz Iqbal,

Objective: To determine the frequency of vitamin D deficiency and insufficiency in a low-income peri-urban population.
Methods: The cross-sectional study was conducted in a low-income, unplanned settlement in Karachi, and comprised apparently healthy adults who were recruited....

Effect of different doses of isotretinoin treatment on the levels of serum homocysteine, vitamin B 12 and folic acid in patients with acne vulgaris: A prospective controlled study

Muhammad Kamal, Muhterem Polat,

Objective: To investigate the effects of different doses of isotretinoin on serum homocysteine, vitamin B12 and folic acid in patients with acne vulgaris.
Methods: The case-control study was conducted at Gazi University School of Medicine, Ankara, Turkey, from November 2012 t....

Doctor! Will I be dry? Factors determining recurrence after vesicovaginal fistula repair

Atif Javed, Aziz Abdullah, Nuzhat Faruqui, Sher Shah Syed, Binat-ul-Mehdi, Abdul Jabbar Pirzada,

Objective: To evaluate various prognostic factors which determine outcome after surgical repair of vesicovaginal fistula.
Methods: The retrospective study was conducted at Koohi Goth Fistula Hospital, Karachi, and comprised data related to patients having undergone vesicovagi....

Analysis of clinical characteristics, rationale, and management of critically ill obstetric patients transferred to ICU

Nailla Yousuf, Shabnam Naz Shaikh, Ahmaduddin Soomro, Rafia Baloch,

Objective: To evaluate the clinical and demographic characteristics, rationale for transfer of critically ill obstetric patients to intensive care unit and their management therein.
Methods: The observational retrospective case series study was conducted at Shaheed Mohtarma B....

Influence of genetic variations in ABCB1 on the clinical efficacy of ondansetron - A pharmacogenetic analysis of Pakistani population

Kulsoom Farhat, Akbar Waheed, Azhar Hussain, Muhammad Ismail, Qaisar Mansoor, Anwar Kamal Pasha, Nusrat Jafery,

Objective: To study the association of C1236T single-nucleotide polymorphisms of ABCB1 gene with non-responsiveness to antiemetic treatment in post-operative patients.
Methods: The prospective, clinical trial was conducted at Combined Military Hospital, Rawalpindi, and the In....

Factors affecting mortality in patients with organophosphate poisoning

Ercan Gunduz, Recep Dursun, Mustafa Icer, Yilmaz Zengin, Mehmet Nezir Gullu, Hasan Mansur Durgun, Osman Gokalp,

Objective: To investigate the relationship between clinical and demographic characteristics and mortality in patients with organophosphate poisoning.
Methods: The retrospective study was conducted at Dicle University,Diyarbakir,Turkey, and comprised data of patients who prese....

Frequency of low bone mineral density in spondyloarthropathy presenting at a tertiary care hospital

Lubna Nazir, Shafique Rehman, Amir Riaz, Mohammad Saeed, Tahira Perveen,

Objective: To determine the frequency and risk factors of low bone mineral density in patients with spondyloarthropathies.
Methods: The cross-sectional study was conducted at the Rheumatology Department of a tertiary care hospital in Karachi between June and November 2014, an....

Bibliometric analysis of the Journal of Pakistan Medical Association form 2009 to 2013

Muhammad Ibrahim, Saeed Ullah Jan,

Objective: To conduct a bibliometric analysis of the Original articles published in the Journal of Pakistan Medical Association.
Methods: The study was conducted in Peshawar and comprised all Original articles published in the Journal of Pakistan Medical Association between 2....

Differences in risk-adjusted outcome of road traffic injuries in urban tertiary care centers of Pakistan

Amber Mehmood, Junaid Abdul Razzak, Mohammed Umer Mir, Rashid Jooma,

Objective: To assess the differences in road injury survival in three tertiary care hospitals in an urban setting.
Methods: The study was conducted in and comprised all road traffic injury victims presenting to the three state-run tertiary care centres in Karachi from Septemb....

Basic neonatal resuscitation, knowledge assessment at primary health care centers of district Sheikhupura in Pakistan - a cross-sectional study

Naila Khalid, Masroor Ahmad, Adeel Tahir, Hassan Mahmood, Shifa Saleem, Sarah Saleem,

Objectives: To assess the knowledge of lady health visitors and midwives working at primary healthcare facilities about neonatal resuscitation.
Methods: The cross-sectional survey was conducted in District Sheikhupura of Pakistan's Punjab province from September to November ....

Type of immune and complement deposits and response of immunosuppressive treatment on Membranoproliferative Glomerulonephritis - a single centre experience

Salman lmtiaz, Murtaza Fakhruddin Dhrolia, Kiran Nasir, Beena Salman, Aasim Ahmad,

Objectives: To see the response of steroid and cyclophosphamide if membranoproliferative glomerulonephritis is classified by pattern of immune and complement deposits.
Methods: The retrospective study was conducted at The Kidney Centre, Karachi, and comprised patients treated....

Risk factors of cardiovascular disease in district Swat

Sohail Akhtar, Naseem Asghar,

Objectives: To identify different risk factors of cardiovascular disease, to examine the association of these risk factors with the disease, and to assess the incidence of the disease in the study region.
Methods: The cross-sectional study was carried out at the Cardiology De....

Short Reports >>

Energy drinks consumption practices among medical students of a Private sector University of Karachi, Pakistan

Asma Usman, Swaleha Tariq Bhombal, Ambreen Jawaid, Samar Zaki,

Consumption of energy drinks has become popular among students and athletes over the past few years. To explore the phenomenon, a cross-sectional survey was conducted through a self-administered pilot-tested questionnaire. Frequency of energy drinks consumption was found to be 121(52%) in a sampl....

Febrile seizrues: demographic, clinical and etiological profile of children admitted with febrile seizures in a tertiary care hospital

Shabbir Hussain, Saba Haider Tarar, Moin Ud Din Sabir,

The hospital-based prospective study was conducted in Combined Military Hospital, Kharian, Pakistan, from January 2012 to December 2013, to determine the demographic, clinical and aetiological profile of paediatric patients admitted with febrile seizures. Patients clinically diagnosed as a case o....

Case Reports >>

Lichen striatus and pityriasis lichenoides chronica in an 11-year-old girl: An etiologic relationship?

Seval Erpolat, Sibel Yenidunya,

Lichen striatusis a rare linear papulardermatosis that primarily occurs in children. The lesions have a linear distribution following Blaschko's lines. Pityriasis lichenoides is an uncommon benign skin disorder with two major variants: acute and chronic.Herein, we report the case of an 11-year-o....

Portomesenteric venous gas does not always mean intestinal necrosis: report of a case

Savas Yuruker, Murat Derebey, Kagan Karabulut, Ismail Alper Tarim, Selim Nural, Ilhan Karabicak, Necati Ozen,

Portomesenteric venous gas is a rare condition most commonly caused by mesenteric ischaemia. Mesenteric ischemia, can be life-threatining and requires immediate surgical intervention with a poor prognosis. During the laparotomy, intestinal necrosis and perforation are most common findings althoug....

Mesonephric adenocarcinoma of the uterine cervix: A case report and review of the literature

Leyla Tekin, Ayse Yazici, Eren Akbaba, Melike Nur Akin,

Mesonephric adenocarcinoma is a rare neoplasm of uterine cervix. It originates from the mesonephric ductus remnant or mesonephric hyperplasia area. There have been few such cases reported. Our case was 64 years of age and her tumour held the whole endocervical wall. It was around 5cm in diameter,....

Spontaneous improvement in sensorineural hearing loss developed as a complication of neonatal hyperbilirubinemia

Sameen Khalid, Maqbool Qadir, Muhammad Sohail Salat,

Icterus neonatorum, or neonatal jaundice, is defined as a total serum bilirubin level above 5mg/dl. Acute bilirubin encephalopathy and kernicterus are known to be the two major complications associated with it, resulting in neurotoxic effects, including sensorineural hearing loss, hypotonia, dela....

Severe hyperparathyroidism in patient with right thyroid hemiagenesis

Mustafa Eroglu, Faruk Ozkul, Ebru Cakan Barutcu, Kasim Arik, Gurhan Adam, Yildiz Bilen, Kubilay Ukinc, Mehmet Asik,

Thyroid hemiagenesis is an infrequent congenital disorder which is rarely associated with hyperparathyroidism. We present a case of an adult woman who presented with hyperparathyroidism and ipsilateral thyroid hemiagenesis. Parathyroid adenoma was excised by minimal invasive parathyroidectomy.

Student's Corner >>

Near complete aortic transection and its successful repair using a novel cardiopulmonary bypass technique

Dania Aijaz Shah, Adil Aijaz Shah, Syed Jawad Shah, Muhammad Naseer Khan, Saulat Hasnain Fatimi,

The case of a 38-year old female, victim of a road traffic accident who presented with a near complete aortic transection is presented. An emergent repair employing cardiopulmonary bypass was attempted in the operating room. Anticipating a high-risk of compromise to cerebral perfusion from air mi....

Recent Advances In Endocrinology >>

Musculoskeletal effects of diabetes mellitus

Rajiv Singla, Yashdeep Gupta, Sanjay Kalra,

People with diabetes show higher prevalence of rheumatic diseases as compared to general population. Diabetes affects all components of musculoskeletal system viz. muscles, bones and connective tissue. Diabetic myonecrosis is a unique condition seen only in people with diabetes. Other diseases in....

Letter To The Eimtor >>

Role of parents in communication development of their children

Sumera Nawaz Malik, Madiha Sikander, Nayab Iftikhar,

Madam, Communication is the activity of conveying information through the exchange of ideas, feelings, intentions, attitudes, expectations, perceptions or commands, as verbal (communication) and non-verbal communication.1 Remember communication begins long before words are ....

Penetrating cardiac trauma by firearm: better outcomes and importance of prehospital care system

Carlos Karigyo, Felipe Batalini,

Madam, we read with great interest the article by Siddiqui et al.: "Surviving shot through the heart: Management in two cases", published recently in the Journal of Pakistan Medical Association.1 This issue is very relevant especially in the current era of growing....

Primary Care Diabetes >>

Infections in diabetes

Atulya Atreja, Sanjay Kalra,

Diabetes Mellitus is a global health problem. Uncontrolled diabetes affects T cell and B cell function, causing increased predisposition to bacterial infections. Increased susceptibility to infections may precipitate metabolic complications in diabetes. Awareness of diabetes related diseases help....


The Bishwa Bandhan Foundation for cerebral Palsy will hold on International Medical Symposium on 2nd September 2015 at Kongresshaus, Zurich, Switzerland to prevent and design a cerebral palsy free world.
This will involve more than 200 countries in the world.



Sindh Institute of Urology and Transplantation (SIUT), Karachi will celebrate 40 years of its services by holding an International Symposium on Recent Advances in Urology, Nephrology, GI Hepatology, Paediatrics, Transplantation & Bioethics from 8th to 12th December, 2015.Social and economic aspects of health care especially in a developing country will also be included. Important Dates: Last date for Abstract submission:31st July 2015 Last Date for early registration: 30. September, 2015





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