Welcome to Journal Of Pakistan Medical Association
   Issue Vol:65, No:11 November, 2015
Editorial >>

Metabolic Syndrome: The drums are beating

Sanjay Kalra, Yashdeep Gupta,

A well described medical condition, the prevalence of Metabolic Syndrome is matched by an equally large number of definitions, monikers, and acronyms. Known by various names such as the Deadly Quartet, Dysmetabolic Syndrome, hypertriglyceridaemic waist, insulin resistance syndrome, Syndrome W, Sy....

Original Articles >>

Comparison of letrazole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation

Maysoon Sharief, Najlaa Rasmee Nafee,

Objective: To compare the efficacy of letrazole in the induction of ovulation with clomiphene citrate in patients with polycystic ovary syndrome and primary infertility.
Methods: The prospective clinical trial was conducted at Basrah Maternity and Child Hospital, Basrah, Iraq....

The association between 25-dehydroxy vitamin D and lower respiratory infection in children aged less than "5" years in Imam Reza hospital, Bojnurd, Iran

Ali Khakshour, Ahmad Shah Farhat, Ashraf Mohammadzadeh, Fatemeh Khorashadi Zadeh, Zhila-Sheikh, Hosein Kamali,

Objective: To clarify the association between vitamin D deficiency and acute respiratory infection in children below age 5 years.
Methods: The cross-sectional study was conducted at Imam Reza Hospital in Bojnurd, Iran, in June 2013 and comprised 90 children below 5 years of a....

Bedside heart type fatty acid binding protein (H-FABP): Is an early predictive marker of cardiac syncope

Bedriye Muge Sonmez, Derya Ozturk, Fevzi Yilmaz, Ertugrul Altinbilek, Cemil Kavalci, Tamer Durdu, Oktay Hakbilir, Turan Turhan, Murat Ongar,

Objective: To determine the value of bedside heart-type fatty acid binding protein in diagnosis of cardiac syncope in patients presenting with syncope or presyncope.
Methods: The prospective study was conducted at Ankara Numune Training and Research Hospital, Ankara, Turkey, ....

Consanguinity ratio in b-thalassemia major patients in District Bannu

Muhammad Sadiq Khan, Mushtaq Ahmed, Rahmat Ali Khan, Nadia Mushtaq, Muhammad Wasim Ullah Shah,

Objective: To assess the frequency of consanguinity in b-thalassemia major patients and its association with age, gender and hepatitis C virus antibody positivity.
Methods: The cross-sectional study was conducted from June 2013 to July 2014 at various hospitals of district Ba....

Role of acute pain service in optimizing postoperative pain relief in a tertiary care teaching hospital

Aliya Ahmed, Muhammad Yasir,

Objective: To assess the frequency and types of adjustments that acute pain service makes to postoperative analgesic regimes to improve pain relief or treat side effects.
Methods: The prospective observational study was conducted at the Aga Khan University Hospital, Karachi, ....

The association of factor V leiden mutation with recurrent pregnancy loss

Sumreen Kashif, Muhammad Ali Kashif, Anjum Saeed,

Objective: To determine the association of factor V Leiden mutation with recurrent pregnancy loss.
Methods: The case-control study was conducted at the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to June 2012, and compris....

Frequency and factors leading to recurrent pre-eclampsia

Mirab Emanuel, Sofia Butt,

Objective: To determine the frequency and factors leading to recurrent preeclampsia.
Methods: The cross-sectional study was conducted at the Jinnah Post Graduate Medical Centre, Karachi, from January 2011 to February 2012, and comprised parous subjects <40 years of age wi....

Frequency of preterm delivery in proteinuric verses non proteinuric pregnancy induced hypertension

Saima Sheikh, Gulfishan Haq, Sarah Kazi,

Objective: To compare the frequency of preterm labour associated with gestational proteinuric hypertension versus gestational non-proteinuric hypertension.
Methods: The prospective cohort study was conducted at the Department of Obstetrics & Gynaecology, Dow University of....

Elevated serum level of human alkaline phosphatase in obesity

Abdul Rehman Khan, Fazli Rabbi Awan, SyedaSadia Najam, Mehboob Islam, Tehmina Siddique, Maryam Zain,

Objective: To investigate a correlation between serum alkaline phosphatase level and body mass index in human subjects.
Methods: The comparative cross-sectional study was carried out at the National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan, fr....

Bcl-2 and p53 expression in hepatic tissues of Egyptian patients with Chronic Hepatitis C

Ahmed Allam, Sami Gabr, Jamaan Ajarem, Mostafa Abdel-Maksoud,

Objective: To investigate B-cell-lymphoma-2 and tumour protein p53 expression in hepatic tissues of human cases of Chronic Hepatitis C.
Methods: The case-control study was conducted from December 2011 to February 2014 at the out-patient department of Gastroenterology Surgical....

Efficacy and safety of semirigid ureteroscopy combined with holmium: YAG laser in the treatment of upper urinary tract calculi: Is it a good alternative treatment option of flexible ureteroscopy for developing countries?

Ozgur Haki Yuksel, Serkan Akan, Ahmet Urkmez, Fatih Uruc, Ayhan Verit,

Objective: To assess the success rates of endoscopic management of upper ureteral stones using semirigid ureterorenoscopy and holmium: YAG laser lithotripters.
Method: A total of 74 patients with an established diagnosis of upper ureteric stone and scheduled for endoscopic ur....

Is chlorhexidine-gluconate superior than Povidone-Iodine in preventing surgical site infections? A multicenter study

Safia Bibi, Syed Aslam Shah, Shamim Qureshi, Taranum Ruba Siddiqui, Iftikhar Ahmed Soomro, Waquaruddin Ahmed, Syed Ejaz Alam,

Objective: To compare the efficacy of povidone-iodine and chlorhexidine gluconate scrubs in preventing surgical site infections.
Methods: The randomised controlled clinical trial was conducted from May 2012 to April 2013 in two public-sector hospitals of Pakistan; one each in....

Prevalence of rheumatoid arthritis in population with arthralgia presenting to a tertiary care hospital

Rehan Shamim, Mohammad Dilawar Jan, Urooj Zafar,

Objective: To evaluate patients presenting to healthcare facilities because of joint pain and subsequently diagnosed with rheumatoid arthritis.
Method: The prospective study was conducted from August 1, 2013,to January 20, 2014, at Jinnah Postgraduate Medical Centre, Karachi,....

Clinical spectrum, management and outcome of neonatal candidiasis

Ejaz Ahmed Khan, Shehla Choudhry, Masooma Fatima, Zahra Batool,

Objective: To identify clinical spectrum, management and outcome of neonatal candidiasis.
Methods: The retrospective study was conducted at the Shifa International Hospital, Islamabad, Pakistan, and comprised microbiological records of all the babies admitted to the Neonatal ....

Respiratory tract infections in diabetic and non-diabetic individuals are linked with serum surfactant protein-D

Shireen Jawed, Marium Saeed, Naila Parveen,

Objective: To find out the rate of respiratory tract infections in diabetic and non-diabetic individuals and their relation with surfactant protein D.
Methods: The cross-sectional study was conducted at Dow University of Health Sciences, Karachi, from September 2011 to April ....

Apprehensions and problems after laryngectomy: Patients' perspective

Ismail Hirani, Atif Hafeez Siddiqui, Iqbal Abdul Muhammad Khyani,

Objectives: To evaluate the apprehensions, social, sexual and financial problems in patients with advanced laryngeal cancer after total laryngectomy and the impact of attending laryngeal club on these problems.
Methods: The analytical study was conducted at the Dow Medical Co....

Intraocular pressure changes associated with tracheal extubation: Comparison of sugammadex with conventional reversal of neuromuscular blockade

Ozgur Yagan, Refika Hande Karakahya, Nilay Tas, Ebru Canakci, Volkan Hanci, Serhan Yurtlu,

Objective: To compare the effects of neostigmine/atropine combination and sugammadex on intraocular pressure during tracheal extubation period.
Methods: The single-blind prospective randomised controlled study was conducted at Ordu University Research and Training Hospital f....

Short Reports >>

Oral manifestations of asthmatic patients

Janan Ghapanchi, Fahimeh Rezazadeh, Fereshte Kamali, Mostafa Rezaee, Maryam Ghodrati, Sara Amanpour,

The effect of asthma on oral health is the subject of debate among dental practitioners. The current study was planned to investigate the oral manifestations of asthmatics compared to healthy subjects. The study group composed of 100 asthmatics and 100 age-matched healthy controls. The caries sta....

Case Reports >>

Laparoscopic resection of gastro-intestinal stromal tumour

Usman Ismat Butt, Ahsan Khan, Allah Nawaz, Mahmood Ayyaz, Rashid Mansoor, Awais Amjad Malik, Tehreem Fatima,

Gastro-Intestinal Stromal Tumours are rare tumours, constituting less than 1% of gastrointestinal tumours. They are the most common mesenchymal origin tumours of gastro-intestinal tract. Tyrosine kinase c-kit oncogene mutation is found in all cases. These tumours are sensitive to imatinib. They a....

Acute dystonic reaction due to dexketoprofen trometamol

Afsin Emre Kayipmaz, Tufan Akin Giray, Suleyman Serdar Tasci, Cemil Kavalci, Ummu Gulsum Kocalar,

Dexketoprofentrometamol (DKP), is a tromethamine salt of the water-soluble S-enantiomer of ketoprofen. As with all other non-steroidal anti-inflammatory agents, the most common side effect of DKP is gastric complications. In this paper, we report a case of dystonic reaction after intravenous DKP ....

An isolated hyoid bone fracture caused by blunt trauma to the neck

Baris Erdogan, Mehmet Ozgur Erdogan, Sahin Colak, Ozge Kibici, Korkut Bozan, Baris Alper,

Hyoid bone fractures due to blunt trauma are exceedingly rare. Here, we present an isolated hyoid bone fracture caused by blunt trauma as well as a detailed discussion of the injury and treatment options.
A 32-year-old male was admitted to emergency department with odynophagia and severe n....

A rare case of isolated macronodular hepatic tuberculosis (Tuberculous) in an immunocompetent patient

Yusuf Kayar, Iskender Ekinci, Figen Tunali Turkdogan, Musa Atay, Rabia Bag Soytas, Nuket Bayram Kayar,

Tuberculosis is one of the most common and well described infectious diseases, with a world wide distribution and a vast spectrum of clinical manifestations. There are three forms of hepatic tuberculosis. Diffuse hepatic involvement with pulmonary or miliary tuberculosis, diffuse hepatic infiltra....

Student's Corner >>

An audit of clinical laboratory data of 25 [OH]D at Aga Khan University as reflecting vitamin D deficiency in Pakistan

Sidra Hassan, Syeda Maria Muzammil, Lena Jafri, Aysha Habib Khan,

Objectives: To estimate the burden of Vitamin D deficiency in people from different geographical areas of Pakistan.
Methods: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised specimens of subjects tested for 25-hydroxy D at the ....

Takotsubo cardiomyopathy (Broken heart syndrome)

Aqib Javed, Kamal Chitkara, Arslan Mahmood, Aleesha Kainat,

Takotsubo cardiomyopathy is an acute reversible cardiomyopathy characterised by transient regional left ventricular (LV) motion abnormalities. It is diagnosed on a coronary angiography and left ventriculography. We report the case of a 50-year-old lady who presented with sudden onset of chest pai....

Letter to the Editor >>

Increased incidence of measles in vaccinated population of Pakistan

Noman Ahmed Jang Khan, Ehsan Faquih, Syed Mojizul Hasan,

Madam, It is a matter of great concern that measles has become one of the major contributor to the mortality and morbidity of children all over the world including Pakistan.1 Measles is caused by RNA virus called as paramyxovirus. It is a highly contagious disease spread ma....

A rare cause of ileus in an infant: a case of gossypiboma

Mehmet Serif Arslan, Serkan Arslan, Ibrahim Uygun,

Madam, Gossypiboma is a rare surgical complication defined as a retained surgical tool, which is mostly a sponge, in the body after a surgical procedure. It may lead to significant morbidity and mortality. Long term non-specific problems seen after surgery should remind us of the differential dia....

Recent Advances In Endocrinology >>

The metabolic score: A decision making tool in diabetes care

Sanjay Kalra, Yashdeep Gupta,

The heterogeneity of diabetes mellitus, and the various metabolic abnormalities associated with it, are well known. Current management guidelines used to help choose glucose-lowering drugs in diabetes mellitus describe various drug classes in detail, but do not take the overall metabolic profile ....

Primary Care Diabetes >>

Pre-conception management of diabetes

Bharti Kalra, Yashdeep Gupta, Sanjay Kalra,

Pre-conception management of diabetes implies the optimization of all biological, social, and psychological factors, prior to conception, in a woman with preexisting type 1 or type 2 diabetes. Pre-conception management includes appropriate counseling, investigations, glycaemic and supportive mana....



Sindh Institute of Urology and Transplantation (SIUT), Karachi will celebrate 40 years of its services by holding an International Symposium on Recent Advances in Urology, Nephrology, GI Hepatology, Paediatrics, Transplantation & Bioethics from 8th to 12th December, 2015.Social and economic aspects of health care especially in a developing country will also be included.

Important Dates: Last date for Abstract submission:31st July 2015 Last Date for early registration: 30th September, 2015






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