Persistent infection with human cytomegalovirus (HCMV) infection is extremely common in many parts of the world. Indeed, in the Pakistani population this is reported to be more than 90%, when measured using HCMV specific IgG antibody.1-4 HCMV-IgMsero-prevalence was 4.3%, bu
Objective: To characterise the clinicopathological features of gastric cancer.
Methods: This retrospective study was conducted at the histopathology laboratory of King Fahad Hospital, Madinah, Saudi Arabia, and comprised record of gastric cancer patients from January 2006 to
Objective: To determine the mean difference in maximum urine flow rate and post-void residual urine volume in sitting as well as standing voiding position in healthy males.
Methods: This descriptive, cross-sectional study was conducted at the Department of Urology, Indus Hosp
Objective: To propose a wavelet-based template matching technique to extract features for automatic classification of electrocardiogram signals of normal and arrhythmic individuals.
Methods: The study was conducted from December 2014 to December 2015 at the Department of Elec
Objective: To assess the ratio of soluble transferrin receptor to ferritin in different stages of chronic kidney disease.
Methods: This case-control study was conducted at the Aga Khan University Hospital and the Jinnah Postgraduate Medical Centre, Karachi, from January to Se
Objective: To determine the association between serum levels of apolipoprotein E, leptin, complimentary factor H and high temperature requirement A-1 in patients with age-related macular degeneration.
Methods: This case-control study was conducted at the Quaid-i-Azam Universi
Objective: To describe the characteristics and assess the factors of mortality in drug-resistant tuberculosis patients.
Methods: This retrospective study was conducted at 11 programmatic management of drug-resistant tuberculosis centres located in different cities of the Punj
Objective: To compare doctoral programmes of nursing in Iran and Canada.
Methods: This qualitative study was conducted in Mashhad, Iran, in April 2014. It was based on Beredy\'s model, including description, interpretation, juxtaposition and comparison. The validity of the
Objective: To compare levels of depression and locate difference in effects of dietary practices on depression severity in housewives and working women.
Methods: This comparative, cross-sectional study was conducted at the University of Karachi and the Dow University of Heal
Objective: To see whether betamethasone gel or lidocaine gel is superior in reducing the incidence of post-operative sore throat after tracheal extubation.
Methods: This clinical study was conducted at the Nishtar Hospital and Medical College, Multan, Pakistan, from July to D
Objective: To determine the effects of sevoflurane by inhalation on female reproductive hormones and ovarian tissues.
Methods: This experimental study was conducted at the Gaziosmanpasa University, Tokat, Turkey, and comprised Wistar-Albino female rats. The rats were divided
Objective: To determine the frequency of depression and anxiety in post-operative patients undergoing elective and emergency surgery.
Methods: The cross-sectional analytical study was conducted at the Department of Surgery and Department of Psychiatry of the Allama Iqbal Memo
Objective: To determine the methods used by nurses working in family health centres to decrease pain during medical procedures in infants.
Methods: This descriptive, cross-sectional study was conducted at family health centres in the county town of Bandirma, and city centres
Objective: To determine what should be done as a preventive medicine physician by analysing the effect of polypharmacy and herbal treatment.
Methods: This survey-based, cross-sectional study was carried out at Istanbul Okmeydani Training and Research Hospital, Istanbul, Turke
Objective: To determine the presence of pathogenic fungal strains in areas where pigeons are present in a large number.
Methods: This study was conducted at the Federal Urdu University of Arts, Science and Technology, Karachi, from February 2015 to March2016, and comprised sa
Helicobacter pylori infection is considered the most commonly prevalent gastrointestinal pathogen where it manages to survive despite the hostile environment of human stomach, leading to various gastric diseases including gastric cancer. Due to the chronic inflammatory state induced by H. pylori
Treatment of chronic hepatitis C (HCV) is difficult in thalassemics due to the haemolytic side effects of therapy. This study evaluated the treatment response to conventional interferon and ribavirin in HCV patients with thalassemia major. It was conducted at PMRC Research Centre, Jinnah Postgrad
Sexual self-esteem is negatively influenced by the stressful experiences in lifetime. This study compared the sexual self-esteem and its components in mothers with normal and mentally-retarded children in Qaen city, in 2014. A total of 120 mothers were selected and assigned into two groups of 60
Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/ m3) through static inhalation for 2 hours per day for
Severe pancreatitis occurs in approximately 15-25% of patients with acute pancreatitis. The objective of our study was to compare the CT Severity Index (CTSI) with a clinical score (BISAP score) to predict severity of acute pancreatitis. Forty-eight consecutive patients with acute pancreatitis wh
Perioperative anaesthetic management of patients with pulmonary hypertensive crisis is complex and challenging because of limited window period and treatment options. This case report describes the successful management of a patient with severe valvular heart disease superimposed by severe pulmon
Neonatal lupus erythematosus is an autoimmune disease resulting from the trans-placental passage of maternal anti-SSA/Ro, anti-SSB/La, and less frequently anti-RNP antibodies to the foetus. At the time of diagnosis 50% of mothers are asymptomatic. Neonatal manifestations of this multisystem disea
Meckel's diverticulum mimicking acute appendicitis is a very rare condition encountered in practice. MD is asymptomatic in most of cases and only about 4 to16% of cases develop complications. Perforation of MD by a foreign body is even rarer being only reported in few cases in the literature. Th
A cross sectional study was conducted in Services Hospital, Lahore using a self administered questionnaire to test the knowledge, attitude and prescribing practices of residents and attending physicians using non-probability convenience sampling. A total of 116 questionnaires were filled (Respons
Thrombotic microangiopathy (TMA) often needs detailed investigations to identify the etiology especially in patients who present with multisystem pathology.
Causes of TMA include thrombotic thrombocytopenic purpura, haemolytic uraemic syndrome, drug-induced TMA, HELLP syndrome, systemic in
Neuwirth with his team perfomed the first hysteroscopic myomectomy in 1976 which largely replaced the conventional surgical interventions and began a new age of minimally invasive gynaecological procedure.1 Soon after the first case, multiple trials and procedures were done
Madam, I read with interest the article by Syed AA et al. in the March 2017 issue of Journal of Pakistan Medical Association.1However, I have a few concerns regarding the methods used in this article. Firstly, a major flaw in the analysis is that Wilcoxon ranked-sum test (M
Thank you Dr. Yakoob for taking interest in our article. Having received your feedback and critique, we would like to respond to the comments.
Firstly, we agree that our data had both before and after values of ALT for patients with severe dengue hepatitis. However to clarify, we did not d
Familial Mediterranean Fever (FMF) is an autosomal recessive and autoinflammatory disease, characterized with inflammation of serous membranes such as peritoneum, pleura, synovium with fever and pain. Colchicine is the main treatment of FMF, but 5-10 % of patients are unresponsive to colchicine.
This case series was done at Armed Forces Institute of Cardiology, National Institute of Heart Disease, Rawalpindi, to observe safety and efficacy of manual vacuum aspiration and frequency of complications in cardiac patients with missed abortion. All cardiac patients presenting in first trimeste
The aim of the present case series was to investigate the causes of hearing loss in the children studying at a primary School for the deaf in Van Province, Turkey. The present series included 95 children with sensorineural hearing loss. Otoscopic and ophthalmological examinations, pure-tone audio
A country\'s higher education depends on the role of organizations and institutions in improving the quality of research. While the Higher Education Commission (HEC) is struggling enough to promote research environment in the universities by spending billions of rupees, output from them stays l
Both diabetes and drug addiction are common phenomena across the world. Drug abuse impacts glycaemic control in multiple ways. It becomes imperative, therefore, to share guidance on drug deaddiction in persons with diabetes. The South Asian subcontinent is home to specific forms and patterns of d
Fats and oils are one of the very important components of diet. However excess of either overall fat or certain kind of fats in the diet may result in negative health impacts including risk of obesity, dyslipidaemia, cardiovascular diseases and certain malignancies. It is thus important to have a
This review focuses on the current literature directed towards the brain metabolite findings in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) disease using magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MR
Low grade glioma is a group of WHO grade II tumours including diffuse astrocytoma, oligodendroglioma, and oligoastrocytoma. Strong evidence exists in literature now to support early surgery and higher extent of safe resection in improving outcomes. In this review, we are highlighting some of the
Incidentaloma, a modern concept connected to technology progress, represents an accidentally discovered tumour, usually used for hypophysis and adrenals, and rarely for thyroid, parathyroids, and ovaries. This is a narrative review based on PubMed research, between 2012 and 2016 focusing on gener
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