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July 2020, Volume 70, Issue 7

Recent Advances In Endocrinology

Orthorexia nervosa

Sanjay Kalra  ( Department of Endocrinology, Bharti Hospital, Karnal, India. )
Nitin Kapoor  ( Department of Endocrinology, Christian Medical College, Vellore, india )
Jubbin Jacob  ( Department of Medicine, Christian Medical College, Ludhiana, India )


Orthorexia nervosa is an eating disorder characterized by an obsessive focus on "healthy" eating, and inflexibility in diet, which leads to clinically significant medical or psychosocial impairment. This review describes the clinical features and management of orthorexia nervosa. Focusing on the endocrine aspects of the syndrome, it explores the multiple bidirectional links between endocrinopathy and orthorexia, as well as endocrine management and orthorexia.

Keywords: Anorexia nervosa, Bulimia nervosa, Diabesity, Eating disorders, Obesity, Type 1 Diabetes, Type 2 diabetes, Medical nutrition therapy.




Eating disorders are defined as disorders that are "characterized by persistent disturbance of eating or eating-related behaviour that results in the altered consumption or absorption of food and that significantly impairs health or psychosocial functioning".1 Orthorexia nervosa is a relatively recently identified eating disorder, coined by Bratman in 1997.2 The term, created from the Greek words orthos (correct) and orexis (appetite), describes persons whose focus on "healthy" diets leads to malnutrition and impairment of health.




Orthorexia nervosa has been defined as an "obsessive focus on dietary practices believed to promote optimum well-being through healthy eating (with inflexible dietary rules, recurrent and persistent preoccupations related to food, compulsive behaviours), with "consequent, clinically significant, impairment (e.g. medical or psychological complications, great distress, and/or impairment in important areas of functioning)".3 Persons with orthorexia exclude foods that they consider unhealthy. An excessive obsession with sources of foodstuffs, the methods used in growing agricultural produce or manufacturing processed food, and data mentioned on food labels, are characteristics of orthorexia nervosa.4 This attitude leads to impaired social behaviour and social relationships, and can impact physical life. The term 'pathologically healthy eating' has also been used to define orthorexia nervosa.5




The presence of orthorexia is clearly felt in the endocrine and metabolic clinic. A Turkish study suggested a prevalence of 15.5% in male and 11.1% in female persons with diabetes. The risk of orthorexia was not related to duration of diabetes, body mass index or educational status.6 Other studies, however, have reported a higher incidence in obese persons.7,8 The problem of orthorexia and related disorders is likely to increase in coming times, due to the wide and rapid dissemination of health related mis-information on various social media platforms. This calls in for a quinary prevention to curb such often encountered information.




Orthorexia nervosa can be diagnosed by validated questionnaires. At least six tools are available; these include Bratman's Orthorexia Test (BOT), ORTO-15, Eating Habits Questionnaire (EHQ), Dusseldorf Orthorexia Scale (DOS), Barcelona Orthorexia Scale (BOS) and Teruel Orthorexia Scale (TOS).3 Ortho-10 has also been used to screen for orthorexia.3,9


Differential Diagnosis


Orthorexia nervosa must be differentiated from healthy orthorexia, which is a "healthy interest in diet, healthy behaviour with regard to diet, and eating healthily as part of one's identity". Orthorexia nervosa has not been included as a diagnostic label in the Diagnostic and Statistical Manual V, or in the International Classification of Diseases-10. In many ways, however, the condition overlaps that of anorexia nervosa and ARFID (avoidant/restrictive food intake disorder). The main difference, though, lies in the underlying motivation for altered food intake.10,11 There is also a distinct social stigma attached to this condition.12


Endocrine Etiopathogenesis


Orthorexia nervosa has a bidirectional relationship with endocrine and metabolic disease. On one hand, orthorexia nervosa may potentially lead to malnutrition13,14 and associated endocrine diseases Macronutrient and micronutrient deficiency may predispose to hypothalamo-pituitary, gonadal and thyroid dysfunction. These clinical presentations may be similar to those seen in anorexia nervosa.15,16 Vitamin D deficiency, manifesting as osteomalacia or rickets, may be precipitated by orthorexia. Glycaemic variability or brittle diabetes can be another feature of orthorexia. In younger individuals, poor nutrition secondary to orthorexia, may also lead to poor attainment of peak bone mass, hypothalamic amenorrhoea and poor pubertal growth and progression. At the same time, endocrinopathy may precipitate orthorexia nervosa. Loss of appetite, as seen in hypothyroidism, hypopituitarism and Addison's disease, may possibly encourage over-critical assessment and evaluation of foods and food labels, prior to consumption. It is ironical that treatment of orthorexia nervosa may precipitate endocrinopathy as well. The use of newer generation antipsychotics which are used to manage orthorexia, can lead to adverse effects such as weight gain and dysglycaemia.17 Management of endocrine diseases has an orthorexic potential as well. Misplaced efforts at weight loss, in persons with obesity, polycystic ovary syndrome, diabetes and hypothalamic obesity, may trigger orthorexia nervosa. This plausible, and frequently encountered complication, is often seen in persons who focus on self-care without seeking expert endocrine opinion. Paradoxically, orthorexia can have therapeutic potential, too. Orthorexia may develop as a coping mechanism to self limit or manage an endocrine condition such as anorexia nervosa.18 Some unique variants of orthorexia are frequently encountered in endocrine practice. These include overzealous avoidance of salt, of cereals, or of carbohydrates, and over consumption of fruits, artificial sweeteners or proteins, in a misinformed effort at healthy eating behaviour. It must be clarified here that the above discussion is based more upon clinical experience than on evidence. However, the relationships described here are useful in facilitating good clinical practice, with respect to both endocrine care and to eating disorder management (Table).




Orthorexia nervosa is best prevented before it occurs. Endocrinologists should practice a person-centred approach to obesity management.19 This implies that the targets and tools for weight loss should be individualized for each patient. Such decisions should be made by both patient and physicians in a shared manner. It should be explained to each person that health is much more than body mass index or weight number. Quinary prevention to curb commonly encountered misinformation about fad diets, rapid weight loss techniques and nonscientifically tested weight losing commercial products will also help to prevent development of orthorexia.20 If orthorexia nervosa does occur, early identification and management is the key to limitation of complications. This is done by screening for orthorexia nervosa in high risk patients. This would include all persons living with conditions that require nutritional management, including obesity, diabetes. NASH, PCOS, dyslipidaemia and cardiovascular disease. Screening can be done clinically by using a simple two-item questionnaire,3 while confirmation of diagnosis may need the use of more elaborate validated instruments.




All health care professionals should be aware of the clinical condition termed as orthorexia nervosa. A comprehensive history taking can reveal symptoms suggestive of orthorexia, and help in timely identification and treatment.




1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition. Washington, DC: American Psychiatric Association; 2013.

2. Orthorexia. Available at: essay/. Cited on 23 January, 2020.

3. Cena H, Barthels F, Cuzzolaro M, Bratman S, Brytek-Matera A, Dunn T, et al. Definition and diagnostic criteria for orthorexia nervosa: A narrative review of the literature. Eat Weight Disord. 2019; 24: 209-246.

4. Dunn TM, Bratman S. On orthorexia nervosa: a review of the literature and proposed diagnostic criteria. Eat. Behav 2016; 21:11-7.

5. Missbach B, Dunn TM, Konig JS. We need new tools to assess orthorexia nervosa. A commentary on "prevalence of orthorexia nervosa among college students based on Bratman's test and associated tendencies". Appetite. 2017; 108:521-4.

6. Anil C, Aritici G, AriH, Tutuncu NB. Prevalence of orthorexia in diabetic patients. Endocrine Abstracts (2015) 37 EP327 | DOI: 10.1530/endoabs.37.EP327

7. Oberle CD, Samaghabadi RO, Hughes EM. Orthorexia nervosa: Assessment and correlates with gender, BMI, and personality. Appetite. 2017; 108:303-10.

8. Dunn TM, Gibbs J, Whitney N, Starosta A. Prevalence of orthorexia nervosa is less than 1%: data from a US sample. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. Eat Weight Disord 2017; 2:185-92.

9. Strahler J, Hermann A, Walter B, Stark R. Orthorexia nervosa: A behavioral complex or a psychological condition? J Behav Addict 2018; 7:1143-56.

10. Zimmerman J, Fisher M. Avoidant/restrictive food intake disorder (ARFID). Curr Probl Pediatr Adolesc Health Care 2017; 47:95-103.

11. Depa J, Barrada J, Roncero M. Are the motives for food choices different in orthorexia nervosa and healthy orthorexia? Nutrients. 2019; 11: 697-710

12. Nevin SM, Vartanian LR. The stigma of clean dieting and orthorexia nervosa J Eat Disord. 2017; 5:37-46.

13. Moroze RM, Dunn TM, Craig Holland J, Yager J, Weintraub P. Micro-thinking about micronutrients: a case of transition from obsessions about healthy eating to near-fatal "orthorexia nervosa" and proposed diagnostic criteria. Psychosomatics. 2015; 56:397-403.

14. Park SW, Kim JY, Go GJ, Jeon ES, Pyo HJ, Kwon YJ: Orthorexia nervosa with hyponatremia, subcutaneous emphysema, pneumomediastimum, pneumothorax, and pancytopenia. Electrolyte Blood Press 2011; 9: 32-37

15. Stoving RK. Mechanisms in endocrinology: Anorexia nervosa and endocrinology: A clinical update. Eur J Endocrinol 2019; 180:R9-27.

16. Misra M, Klibanski A. Anorexia nervosa and its associated endocrinopathy in young people. Horm Res Paediatr. 2016; 85:147-57.

17. Holt RI. Association between antipsychotic medication use and diabetes. Curr Diabetes Rep 2019; 19:96-105.

18. Barthels F, Meyer F, Huber T, Pietrowsky R. Orthorexic eating behaviour as a coping strategy in patients with anorexia nervosa. Eat Weight Disord 2017; 22:269-76.

19. Medical nutrition therapy in obesity - A person centred approach. Available from URL: insight/medical-nutrition-therapy-in-obesity-a-person centredapproach. Cited on January 23, 2020.

20. Kalra S, Kumar A. Quinary prevention: Defined and conceptualized. J Pak Med Assoc. 2019; 69:1765-66.


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