The potential advantages of the long-acting insulin analogues are reviewed in this special supplement of Journal of Pakistan Medical Association (JPMA).
As shown in many clinical studies of basal insulin vs. regular insulin there are no improvement in HbA1c levels; however, the ability to achieve improvement of HbA1c is often limited by hypoglycemia. Thus, in real-world settings, improvements in fact do occur. The findings from the study "Cost-effectiveness of insulin analogues for diabetes mellitus."by Chris G. Cameron MSc, Heather A. Bennett BPharm PhD (CMAJ 2009;180(4):400-7) suggest that treatment wit