SMARCA4/BRG1-deficient NSCLC: a case report and literature review Authors He Zhang Department of Respiratory and Critical Care Medicine, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, China Xiong-wen Tu Department of Respiratory and Critical Care Medicine, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, China Yu-qing Wei Department of Respiratory and Critical Care Medicine, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, China Zheng-zheng Ni Department of Thoracic Surgery, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, China Liang Cheng Department of Medical Imaging, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, China Juan Wu Department of Pathophysiology, Wannan Medical College, Wuhu, China DOI: https://doi.org/10.47391/JPMA.22492 Keywords: NSCLC, SMARCA4-deficient, Treatment, Prognosis Abstract Patients with non-small cell lung cancer (NSCLC) deficient in SMARCA4 (SMARCA4-dNSCLC) are commonly diagnosed at advanced stages with a poor prognosis. Although immune checkpoint inhibitors (ICIs) combined with platinum-based chemotherapy regimens are widely used, their efficacy in SMARCA4-dNSCLC patients remains suboptimal. Herein, we present the case of a SMARCA4-dNSCLC patient treated at Yijishan Hospital on January 18, 2023. Following our comprehensive treatment, our patient's general condition and quality of life (QOL) have remained satisfactory, and there has been no disease progression to date. Keywords: NSCLC, SMARCA4-deficient, Treatment, Prognosis. Downloads Full Text Article Published 2025-09-25 How to Cite He Zhang, Xiong-wen Tu, Yu-qing Wei, Zheng-zheng Ni, Liang Cheng, & Wu, J. (2025). SMARCA4/BRG1-deficient NSCLC: a case report and literature review. Journal of the Pakistan Medical Association, 75(10), 1621–1624. https://doi.org/10.47391/JPMA.22492 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 10 (2025): OCTOBER Section CASE REPORT License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.