Cronkhite-Canada Syndrome- The first case from Pakistan: a case report Authors Hassan Tanvir Ramzi Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan Yumna Zainab Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan Sana Manzoor Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan Akram Malik Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan DOI: https://doi.org/10.47391/JPMA.6230 Abstract Chronkhite-Canada Syndrome is characterised by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, cutaneous hyperpigmentation, alopecia, diarrhoea, weight loss, and abdominal pain. This disease is also associated with peripheral neuropathies and autoimmune disorders. Its association with other diseases may cause the polyps to turn into malignant tumours and worsen the condition. The first-line treatment is a combination of prednisone and mesalamine. NSAIDs and antibiotic administration is based on the symptoms and needs of patients. Here, we describe a 51-year-old male who presented to us with abdominal pain and significant weight loss. His physical examination showed dystrophic nails, alopecia and hyperpigmentation. Endoscopy and colonoscopy showed multiple polyps. His manifestations were consistent with Cronkhite-Canada syndrome. We prescribed oral corticosteroids, which improved his condition. Keywords: Cronkhite-Canada syndrome, CCS, polyps, Pakistan. Author Biographies Yumna Zainab , Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan House officer , Department of medicine Sana Manzoor, Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan House officer , Department of medicine Akram Malik, Department of Medicine, Ibne Siena Hospital and Research Institute, Multan, Pakistan Assistant professor department of medicine Downloads Full Text Article Published 2023-02-15 How to Cite Hassan Tanvir Ramzi, Zainab , Y., Sana Manzoor, & Malik, A. (2023). Cronkhite-Canada Syndrome- The first case from Pakistan: a case report. Journal of the Pakistan Medical Association, 73(3), 693–696. https://doi.org/10.47391/JPMA.6230 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 3 (2023): March Section CASE REPORT License Copyright (c) 2020 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.